High purity nano hydroxyapatite, 3D printing nano hydroxyapatite, thermal spraying nano hydroxyapatite

Performance features:
The theoretical composition of hydroxyapatite is CA10 (PO4) 6 (OH) 2 and Ca / P is 1.67. However, due to the influence of preparation process, its real composition is quite complex. HA crystal belongs to hexagonal system, belongs to l6pc symmetry type and p63 / M space group. Its structure is hexagonal column, and the plane perpendicular to c axis is a hexagon with an angle of 120 ° between a and B axes. Its unit cell parameters are a = 9.43 ~ 9.38 Å, C = 6.88 ~ 6.86 Å, z = 2. The unit cell contains 10 Ca2 +, 6 PO43 - and 2 Oh -. There are several possible surface states on HA microcrystalline surface: (1) when Oh is located on the crystal surface, oh is connected with two Ca (Ⅱ) ions. When HA is in aqueous solution, the oh position on the surface is vacant at least for a certain moment Ca (Ⅱ) ions are positively charged, forming an adsorption site, which can adsorb PO43 - or phosphate or carboxyl groups on macromolecules. (2) When Ca ion is located on the surface of the crystal, because Ca (I) is connected with six negatively charged O atoms, when ha In aqueous solution, when the Ca (I) site on the surface is vacant at a certain moment, a strong adsorption site is formed at the Ca (I) site, which can adsorb cations such as SR3 +, K + and protein molecules, while a weak adsorption site is formed at the Ca (II) position. (3) When PO43 - is located on the surface of the crystal, H2O binds to PO43 - ion through hydrogen bond.

As a drug carrier, hydroxyapatite has many advantages, such as good biocompatibility, low pH sensitivity, controllable structure, high drug loading, high encapsulation efficiency, etc. At the same time, the surface modification of hydroxyapatite can also solve the problem of sudden release.

As bone repair material, hydroxyapatite material has similar structure with human tooth bone, and has good biocompatibility, so it is widely used in bone defect repair. The results show that nano fibrous hydroxyapatite or porous network hydroxyapatite prepared by controlled conditions is conducive to osteoblast attachment, pore structure is conducive to osteoblast growth and differentiation, and can play a role in promoting bone repair and growth. At the same time, when combined with other antibacterial methods, it can obtain dual functional materials with promoting bone growth and anti infection, which is a research hotspot.

As a new anti-tumor weapon, studies have shown that nano hydroxyapatite has excellent anti-tumor activity. Its anti-tumor mechanism is the negative regulation of mitochondrial dependent apoptosis pathway and pik3 / Akt pathway, which is of great value for the development of advanced biocompatible nanocrystals for nanomedicine.

application prospect

Simple hydroxyapatite materials can not meet the needs of today, more is to seek the combination of hydroxyapatite and other materials, and develop multifunctional composite materials based on the excellent characteristics of hydroxyapatite: for example, hydroxyapatite is combined with Au and Ag to obtain antibacterial composite materials; hydroxyapatite is combined with carbon point to use the radiation property of carbon point In addition, magnetic iron oxide was used to combine with hydroxyapatite to obtain targeted anti-tumor drug carrier.

The functions of hydroxyapatite are as follows: 1) after hydroxyapatite is implanted into bone, it can induce undifferentiated mesenchymal cells to differentiate into osteoblasts, and the latter can directly adhere to the surface of hydroxyapatite. ② In terms of chemical composition, hydroxyapatite is composed of calcium and phosphorus. These two components are the most common components of bone tissue, and calcium salt of bone tissue is composed of crystalline apatite and amorphous phosphoric acid. Therefore, hydroxyapatite bone substitute material is consistent with calcium salt in human bone tissue not only in composition but also in structure

The clinical application range of bioceramics is artificial joint, bone substitute, toothpaste, food and so on

Hydroxyapatite (HA) is similar to the inorganic components of human bone, and has good biological activity and biocompatibility. Compared with the traditional metal (stainless steel, titanium alloy) and ceramic (alumina, silicon nitride) bone substitute materials, hydroxyapatite not only has strong corrosion resistance and bone induction, but also eliminates the safety risks of the former by its degradation in vivo.
3D printing hydroxyapatite is an ideal ceramic resin for biomedical applications.
Combined with the prodways promaker V6000 ceramic 3D printer, it can produce biocompatible, non absorbable components with a chemical structure close to bone, with very high details such as implants, prostheses and bone substitutes for reconstruction surgery.